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SRF / Serum Response Factor

serum response factor (c-fos serum response element-binding transcription factor)

SRF / Serum Response Factor is a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: serum response factor (c-fos serum response element-binding transcription factor)
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: SRF, Serum response factor, MCM1
Target Sequences: NM_003131 NP_003122.1 P11831

Publications (1)

1
An Alternative Promoter in Intron1 of the Renin Gene is Regulated by Glucose Starvation via Serum Response Factor. Philipp Lutze, Heike Wanka, Inga Bäumgen, Doreen Staar, Bianka Grunow, Jörg Peters. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017 July;42:1447-1457. [Full Text Article] [PubMed:28715805]

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
SRF / Serum Response Factor (7)
No (7)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (5)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (2)
SRF / Serum Response Factor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
53.6 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
SRF / Serum Response Factor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51.4 kDa
100 µg/$494
SRF / Serum Response Factor Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SRF / Serum Response Factor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
SRF / Serum Response Factor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51.4 kDa
20 µg/$150
SRF / Serum Response Factor Protein - Purified recombinant protein SRF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
51.4 kDa
20 µg/$1,107
SRF / Serum Response Factor Protein
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E. coli
His-T7
28.5 kDa
50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).