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SREBF2 / SREBP2
sterol regulatory element binding transcription factor 2
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
| Gene Name: | sterol regulatory element binding transcription factor 2 |
| Synonyms: | SREBF2, SREBP2, SREBP-2, BHLHd2 |
| Target Sequences: | NM_004599 NP_004590.2 Q12772 |
Publications (3)
1
Effect of cholesterol reduction on receptor signaling in neurons. Fukui K, Ferris HA, Kahn CR. The Journal of biological chemistry. 2015 290:26383-92. (WB; Mouse)
[Full Text Article]
[PubMed:26370080]
[PMC:PMC4646295]
Related Antibodies: LS-B1609.
2
Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR. Proceedings of the National Academy of Sciences of the United States of America. 2017 January;114:1189-1194. (Human)
[Full Text Article]
[PubMed:28096339]
[PMC:PMC5293102]
Related Antibodies: LS-B1609.
3
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice. Giulia Birolini , Marta Valenza , Eleonora Di Paolo , Elena Vezzoli, Francesca Talpo, Claudia Maniezzi, Claudio Caccia, Valerio Leoni, Franco Taroni, Vittoria D Bocchi, Paola Conforti, Elisa Sogne, Lara Petricca, Cristina Cariulo, Margherita Verani, Andrea Caricasole, Andrea Falqui, Gerardo Biella, Elena Cattaneo. EMBO molecular medicine. 2020 October;12:e12519. [Full Text Article]
[PubMed:32959531]
[PMC:PMC7539329]
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(27)
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(4)
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(4)
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(4)
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(1)
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(19)
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aa399-427
(7)
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(4)
aa434-483
(4)
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(1)
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SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa455-469) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Mouse, Dog, Human, Monkey
ICC, IHC-P, WB
Unconjugated
1 Each/$485
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) (HRP) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) (Biotin) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa304-353) (FITC) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) (HRP) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa434-483) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Hamster, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
SREBF2 / SREBP2 Rabbit anti-Zebrafish Polyclonal (aa441-473) Antibody
Zebrafish
WB
Unconjugated
400 µl/$393
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal (aa399-427) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$406
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SREBF2 / SREBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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