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SRD5A2L / SRD5A3
steroid 5 alpha-reductase 3
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
| Gene Name: | steroid 5 alpha-reductase 3 |
| Synonyms: | SRD5A3, CDG1P, KRIZI, SRD5A2L, S5AR 3, SR type 3, SRD5A2L1, Steroid 5 alpha-reductase 3, Steroid 5-alpha-reductase 3, CDG1Q, Probable polyprenol reductase |
| Target Sequences: | NM_024592 NP_078868.1 Q9H8P0 |
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