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SPTLC1 / HSN1

serine palmitoyltransferase, long chain base subunit 1

Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.

Gene Name: serine palmitoyltransferase, long chain base subunit 1
Synonyms: SPTLC1, HSAN1, HLCB1, HSAN, LCB1, HSN1, LCB 1, Serine palmitoyltransferase 1, SPTI, SPT 1, Serine C-palmitoyltransferase, LBC1, SPT1
Target Sequences: NM_006415 NP_006406.1 O15269

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
SPTLC1 / HSN1 (7)
No (7)
GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (4)
Mouse (1)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
SPTLC1 / HSN1 Protein - 12.5% SDS-PAGE of human SPTLC1 stained with Coomassie Blue
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Wheat Germ Extract
GST
36.85 kDa
10 µg/$479; 25 µg/$670
SPTLC1 / HSN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.6 kDa
20 µg/$215
SPTLC1 / HSN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
15.9 kDa
20 µg/$150
SPTLC1 / HSN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.9 kDa
100 µg/$494
SPTLC1 / HSN1 Protein - Purified recombinant protein SPTLC1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
52.6 kDa
20 µg/$1,107
SPTLC1 / HSN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.6 kDa
100 µg/$710
SPTLC1 / HSN1 Protein - Recombinant  Serine Palmitoyltransferase, Long Chain Base Subunit 1 By SDS-PAGE
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E. coli
His-T7
40.3 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).