SPT5 / SUPT5H

suppressor of Ty 5 homolog (S. cerevisiae)

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

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Products

Antibodies (21)

Proteins (7)

Type

Over-Expression Lysate (2)

Primary (21)

Recombinant (5)

Target

SPT5 / SUPT5H (28)

Reactivity

Human (21)

Mouse (8)

Rat (3)

Bovine (6)

Chicken (3)

Chimpanzee (6)

Dog (6)

Gibbon (6)

Guinea pig (6)

Horse (6)

Monkey (6)

Orangutan (6)

Pig (6)

Rabbit (6)

more less

Application

IHC (7)

IHC-P (7)

WB (19)

ELISA (7)

IF (1)

IP (1)

Host

rabbit (20)

mouse (1)

Isotype

IgG (18)

IgG2b,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (20)

Clone

3F1 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (10)

Epitope

aa395-424 (7)

aa396-445 (4)

aa892-941 (4)

aa1040-C-term (2)

aa50-100 (1)

Publications

No (28)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (1)

HEK 293 Cells (5)

Wheat Germ Extract (1)

Select

SPT5 / SUPT5H Antibody (aa1040-C-term) LS-C287720

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa1040-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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SPT5 / SUPT5H Antibody (clone 3F1) LS-C133459

Antibody:

SPT5 / SUPT5H Mouse anti-Human Monoclonal (3F1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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SPT5 / SUPT5H Antibody (aa396-445) LS-C101478

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa396-445) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SPT5 / SUPT5H Antibody (aa396-445, HRP) LS-C430198

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa396-445) (HRP) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SPT5 / SUPT5H Antibody (aa396-445, Biotin) LS-C430196

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa396-445) (Biotin) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SPT5 / SUPT5H Antibody (aa396-445, FITC) LS-C430197

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa396-445) (FITC) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPT5 / SUPT5H Antibody (aa892-941) LS-C29806

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa892-941) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SPT5 / SUPT5H Antibody (aa892-941, HRP) LS-C429175

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa892-941) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SPT5 / SUPT5H Antibody (aa892-941, Biotin) LS-C429462

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa892-941) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SPT5 / SUPT5H Antibody (aa892-941, FITC) LS-C429174

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa892-941) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPT5 / SUPT5H Antibody (aa395-424) LS-C325499

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SPT5 / SUPT5H Antibody (aa395-424, Biotin) LS-C270735

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SPT5 / SUPT5H Antibody (aa395-424, FITC) LS-C270736

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SPT5 / SUPT5H Antibody (aa395-424, APC) LS-C270734

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SPT5 / SUPT5H Antibody (aa395-424, PE) LS-C270738

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

SPT5 / SUPT5H Antibody (aa395-424, Azide-free, HRP) LS-C270737

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

SPT5 / SUPT5H Antibody (aa1040-C-term) LS-C286458

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa1040-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

SPT5 / SUPT5H Antibody LS-C410727

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

SPT5 / SUPT5H Antibody (aa395-424) LS-C161620

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa395-424) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

SPT5 / SUPT5H Antibody LS-C668098

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

SPT5 / SUPT5H Antibody (aa50-100) LS-C287713

Antibody:

SPT5 / SUPT5H Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

SPT5 / SUPT5H Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125120

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.3 kDa

Price:

100 µg/$710

Select

Human SPT5 / SUPT5H Protein (Recombinant GST, N-terminus) (aa981-1087) - LS-G60252

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human SPT5 / SUPT5H Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67375

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.8 kDa

Price:

20 µg/$1,107

Select

Human SPT5 / SUPT5H Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67378

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.3 kDa

Price:

20 µg/$1,107

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