SPRTN / C1orf124

SprT-like N-terminal domain

Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

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Products

Antibodies (15)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (15)

Recombinant (1)

Target

SPRTN / C1orf124 (18)

Reactivity

Human (15)

Mouse (2)

Rat (2)

Chimpanzee (6)

Application

IHC (5)

IHC-P (1)

WB (10)

ELISA (5)

Host

rabbit (15)

Isotype

IgG (7)

Clonality

polyclonal pc (15)

Format

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

Unconjugated (6)

Epitope

C-Terminus (4)

aa186-235 (4)

Publications

No (18)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

SPRTN / C1orf124 Antibody (aa186-235) LS-C170619

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (aa186-235) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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SPRTN / C1orf124 Antibody (aa186-235, HRP) LS-C476376

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (aa186-235) (HRP) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SPRTN / C1orf124 Antibody (aa186-235, Biotin) LS-C476374

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (aa186-235) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SPRTN / C1orf124 Antibody (aa186-235, FITC) LS-C476375

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (aa186-235) (FITC) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPRTN / C1orf124 Antibody LS-C379363

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

SPRTN / C1orf124 Antibody (HRP) LS-C379361

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

SPRTN / C1orf124 Antibody (Biotin) LS-C379365

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

SPRTN / C1orf124 Antibody (FITC) LS-C379364

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPRTN / C1orf124 Antibody LS-C831925

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

SPRTN / C1orf124 Antibody (C-Terminus) LS-C186903

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SPRTN / C1orf124 Antibody (C-Terminus, HRP) LS-C476373

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SPRTN / C1orf124 Antibody (C-Terminus, Biotin) LS-C476371

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SPRTN / C1orf124 Antibody (C-Terminus, FITC) LS-C476372

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPRTN / C1orf124 Antibody LS-C747038

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

SPRTN / C1orf124 Antibody LS-C747060

Antibody:

SPRTN / C1orf124 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

Human SPRTN / C1orf124 Protein (Recombinant GST) (Full Length) - LS-G35635

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.5 kDa

Price:

2 µg/$439

Select

Human SPRTN / C1orf124 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85394

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

20 µg/$150

Select

SPRTN / C1orf124 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109086

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

100 µg/$494

Viewing 1-18 of 18 product results

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