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SPPL2A / IMP3
signal peptide peptidase like 2A
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity.
| Gene Name: | signal peptide peptidase like 2A |
| Family/Subfamily: | Protease , Aspartic A22B |
| Synonyms: | SPPL2A, IMP-3, Intramembrane protease 3, PSL2, Presenilin-like protein 2, SPP-like 2A |
| Target Sequences: | NM_032802 NP_116191.2 Q8TCT8 |
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