SPHK2

sphingosine kinase 2

Unlike the proliferative action of SPHK1, SPHK2 has been shown to possess anti-proliferative or pro-apoptotic action. SphK2 suppresses growth and enhances apoptosis, independent of activation of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in Bcl2-homology domain 3 (BH3)- only proteins, a pro-apoptotic subgroup of the Bcl-2 family. Co-immunoprecipitation demonstrated that SphK2 interacted with Bcl-xL; however, mutation of the conserved leucine residue present in all BH3 domains only partially reduced apoptosis induced by SphK2, suggesting that the SphK2 protein possesses additional determinants important for this function.

☰ Filters

Products

Antibodies (37)

ELISA Kits (3)

Proteins (3)

Type

Cell-Based (1)

Custom (1)

Primary (37)

Recombinant (3)

Sandwich (1)

Target

SPHK2 (43)

Reactivity

Human (39)

Mouse (12)

Rat (8)

Application

IHC (29)

IHC-P (6)

WB (30)

Flo (5)

ELISA (22)

ICC (1)

IF (2)

IP (1)

Peptide-ELISA (4)

Host

rabbit (35)

mouse (2)

Product Group

IHCPlus (1)

Isotype

IgG (25)

IgG1 (2)

Clonality

monoclonal mc (2)

polyclonal pc (35)

Clone

3C8D3 (1)

9C5E1 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (3)

DY488 Conjugated (1)

DY550 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (22)

more less

Epitope

N-Terminus (11)

aa590-620 (7)

550-630 aa (2)

C-Terminus (2)

pThr614 (2)

Ab-614 (1)

aa52-84 (1)

aa580-629 (1)

Publications

No (43)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (1)

Species

Human (3)

Source

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Select

IHC-plus™ SPHK2 Antibody (N-Terminus) LS-B1101

(4.0) Rating

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

Select

Mouse SPHK2 (Sandwich ELISA) ELISA Kit - LS-F14314

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

Select

SPHK2 Antibody (aa580-629) LS-C118372

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa580-629) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

SPHK2 Antibody (aa590-620) LS-C100772

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

SPHK2 Antibody (C-Terminus) LS-C368753

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351

Select

Human SPHK2 Protein (Recombinant GST) (Full Length) - LS-G34578

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

95.6 kDa

Price:

10 µg/$479; 25 µg/$670

Select

SPHK2 Antibody LS-C801838

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$282; 200 µl/$350

Select

SPHK2 Antibody (phospho-Thr614) LS-C199598

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (pThr614) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

SPHK2 Antibody (clone 9C5E1) LS-C669354

Antibody:

SPHK2 Mouse anti-Human Monoclonal (9C5E1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC

Format:

Unconjugated

Price:

100 µl/$459

Select

SPHK2 Antibody (clone 3C8D3) LS-C669356

Antibody:

SPHK2 Mouse anti-Human Monoclonal (3C8D3) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC

Format:

Unconjugated

Price:

100 µl/$459

Select

SPHK2 Antibody LS-C662532

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, WB

Format:

Unconjugated

Price:

100 µg/$470

Select

SPHK2 Antibody LS-C754208

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SPHK2 Antibody (N-Terminus) LS-C330672

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SPHK2 Antibody (N-Terminus, Biotin) LS-C245953

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SPHK2 Antibody (N-Terminus, FITC) LS-C245954

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SPHK2 Antibody (N-Terminus, APC) LS-C245952

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SPHK2 Antibody (N-Terminus, PE) LS-C245955

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE

Select

SPHK2 Antibody (aa590-620) LS-C328732

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SPHK2 Antibody (aa590-620, Biotin) LS-C245957

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SPHK2 Antibody (aa590-620, FITC) LS-C245959

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SPHK2 Antibody (aa590-620, APC) LS-C245958

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SPHK2 Antibody (aa590-620, PE) LS-C245964

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (aa590-620) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE

Select

SPHK2 Antibody (Ab-614) LS-C827668

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (Ab-614) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SPHK2 Antibody LS-C401405

Antibody:

SPHK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

SPHK2 Antibody (550-630 aa) LS-C386155

Antibody:

SPHK2 Rabbit anti-Human Polyclonal (550-630 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Viewing 1-25 of 43 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.