Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
SPG21 / MAST binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants.
Gene Name: | spastic paraplegia 21 (autosomal recessive, Mast syndrome) |
Synonyms: | SPG21, ACP33, Acid cluster protein 33, BM-019, Maspardin, GL010, MAST, Spastic paraplegia 21 protein |
Target Sequences: | NM_016630 NP_057714.1 Q9NZD8 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.