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SPECC1 / CYTSB

sperm antigen with calponin homology and coiled-coil domains 1

The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: SPECC1, CYTSB, Cytospin-B, HCMOGT-1, Structure protein NSP5a3b, Structure protein NSP5b3a, Structure protein NSP5b3b, Structure protein NSP5a3a, HCMOGT1, NSP, NSP5, Nuclear structure protein 5, Sperm antigen HCMOGT-1
Target Sequences: NM_001033554 NP_001028726.1 Q5M775

Publications (2)

1
NSP 5a3a: a potential novel cancer target in head and neck carcinoma. D'agostino L, Giordano A. Oncotarget. 2010 1:423-35. (WB; Human) [PubMed:21311098] [PMC:PMC3248119]
2
A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma. D'Agostino L, Giordano A. Oncotarget. 2011 2:1055-74. (ICC, WB, IP; Human) [PubMed:22170762] [PMC:PMC3282067]

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
SPECC1 / CYTSB (5)
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GST, N-terminus (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (3)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
SPECC1 / CYTSB Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
SPECC1 / CYTSB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
110.1 kDa
20 µg/$150
SPECC1 / CYTSB Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SPECC1 / CYTSB Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
110.1 kDa
100 µg/$494
SPECC1 / CYTSB Protein - Recombinant  Cytospin B By SDS-PAGE
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E. coli
His-T7
15.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).