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The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development.
Gene Name: | Sperm Associated Antigen 4 |
Synonyms: | SPAG4, Cancer/testis antigen 127, CT127, Acrosomal protein ACR55, SUN4, Sperm associated antigen 4, Sperm tail protein |
Target Sequences: | NM_003116 NP_003107.1 Q9NPE6 |
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