SP1

Sp1 transcription factor

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

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Products

ELISA Kits (9)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (3)

DNA Binding (1)

Sandwich (2)

Target

SP1 (9)

Reactivity

Human (6)

Mouse (5)

Rat (6)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (5)

Publications

No (9)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (2)

Nuclear Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

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Mouse/Human/Rat SP1 (DNA-Binding ELISA) ELISA Kit - LS-F798

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Mouse/Human/Rat Phospho-SP1 (Thr739) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1620

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

2 Plates/$668

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Mouse/Human/Rat Phospho-SP1 (Thr453) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1223

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

2 Plates/$668

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Mouse/Human/Rat SP1 (Cell-Based ELISA) ELISA Kit - LS-F3312

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Rat SP1 (Sandwich ELISA) ELISA Kit - LS-F33441

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse SP1 (Custom ELISA) ELISA Kit - LS-F17823

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human SP1 (Custom ELISA) ELISA Kit - LS-F17821

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Rat SP1 (Custom ELISA) ELISA Kit - LS-F17822

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human SP1 (Sandwich ELISA) ELISA Kit - LS-F39629

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$792

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