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SOX6 is a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.
Gene Name: | SRY (sex determining region Y)-box 6 |
Family/Subfamily: | Transcription factor |
Synonyms: | SOX6, HSSOX6, SOXD, SRY-box containing gene 6, Transcription factor SOX-6 |
Target Sequences: | NM_033326 NP_059978.1 P35712 |
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