SOCS3

suppressor of cytokine signaling 3

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

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Products

Proteins (11)

Type

Recombinant (11)

Target

SOCS3 (11)

Publications

No (11)

Tag

6His, N-terminus (1)

GST (1)

His (4)

His, N-Terminal (2)

His-SUMO (1)

His-TRX (1)

Myc-DDK (Flag) (1)

Species

Human (6)

Mouse (2)

Rat (3)

Source

E. coli (8)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (3)

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Human SOCS3 Protein (Recombinant 6His, N-terminus) (aa1-225) - LS-G14146

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.3 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Human SOCS3 Protein (Recombinant GST) (Full Length) - LS-G31430

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.49 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SOCS3 Protein (Recombinant His-TRX) (Met1-Leu225) - LS-G97906

Source:

E. coli

Tag:

His-TRX

Molecular Weight:

41.9 kDa

Price:

50 µg/$721

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Human SOCS3 Protein (Recombinant His, N-Terminal) (Val2-Leu225) - LS-G96927

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

27 kDa

Price:

10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315

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Human SOCS3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67421

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.6 kDa

Price:

20 µg/$1,107

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Mouse SOCS3 Protein (Recombinant His, N-Terminal) - LS-G132847

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26kDa

Price:

10 µg/$323; 50 µg/$702; 200 µg/$1,298; 100 µg/$1,096; 1 mg/$2,562; 500 µg/$2,060; 5 mg/$4,901; 2 mg/$2,753

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Rat SOCS3 Protein (Recombinant His-SUMO) (Full Length) - LS-G21207

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

40.79 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat SOCS3 Protein (Recombinant His) (Full Length) - LS-G23142

Source:

Yeast

Tag:

His

Molecular Weight:

26.81 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human SOCS3 Protein (Recombinant His) - LS-G2806

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Mouse SOCS3 Protein (Recombinant His) (aa1-225) - LS-G14144

Source:

E. coli

Tag:

His

Molecular Weight:

26.3 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Rat SOCS3 Protein (Recombinant His) (aa1-225) - LS-G14145

Source:

E. coli

Tag:

His

Molecular Weight:

26.3 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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