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SOCS3
suppressor of cytokine signaling 3
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
| Gene Name: | suppressor of cytokine signaling 3 |
| Synonyms: | SOCS3, Cish3, Cytokine-induced SH2 protein 3, CIS-3, CIS3, SSI-3, STAT-induced STAT inhibitor 3, SSI3, ATOD4, SOCS-3 |
| Target Sequences: | NM_003955 NP_003946.3 O14543 |
Publications (3)
1
Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. Persico M, Capasso M, Russo R, Persico E, Croc L, Tiribelli C, Iolascon A. Gut. 2008 57:507-15.
[PubMed:17881539]
2
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:14948-53.
[PubMed:19706421]
[PMC:PMC2736463]
3
Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways. Nguyen KD, Macaubas C, Nadeau KC, Truong P, Yoon T, Lee T, Park JL, Mellins ED. Blood. 2011 117:3793-8.
[PubMed:21325601]
[PMC:PMC3296631]
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Publications
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(79)
SOCS3 Mouse anti-Human Monoclonal (OTI11C5) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI11C5) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Sheep, Bovine, Mouse, Dog, Rat, Pig, Human
WB
Unconjugated
100 µl/$299
SOCS3 Mouse anti-Human Monoclonal (OTI8G3) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI8G3) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Mouse anti-Human Monoclonal (OTI5D4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI5D4) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Goat anti-Human Polyclonal (aa213-225) Antibody
Rabbit, Mouse, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
SOCS3 Rabbit anti-Human Polyclonal (aa71-85) Antibody
Chicken, Sheep, Bovine, Rat, Pig, Horse, Bat, Mouse, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SOCS3 Mouse anti-Human Monoclonal (OTI3D3) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI3D3) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$512
SOCS3 Rabbit anti-Mouse Polyclonal (aa1-225) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
SOCS3 Rabbit anti-Mouse Polyclonal (aa1-225) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
SOCS3 Mouse anti-Human Monoclonal (OTI7E10) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI7E10) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
SOCS3 Mouse anti-Human Monoclonal (OTI3B8) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI3B8) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Mouse anti-Human Monoclonal (OTI6C2) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI6C2) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Mouse anti-Human Monoclonal (OTI15F9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI15F9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SOCS3 Mouse anti-Human Monoclonal (SO1) Antibody
Human
ICC, IF, WB
Unconjugated
100 µg/$503
SOCS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SOCS3 Mouse anti-Human Monoclonal (OTI6F3) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
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