SOCS3

suppressor of cytokine signaling 3

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

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Products

Antibodies (79)

ELISA Kits (25)

Proteins (11)

Type

Custom (3)

Primary (79)

Recombinant (11)

Sandwich (19)

Sandwich CLIA (3)

Target

SOCS3 (115)

Reactivity

Human (65)

Mouse (28)

Rat (29)

Bat (2)

Bovine (3)

Cat (1)

Chicken (4)

Dog (2)

Guinea pig (2)

Hamster (1)

Horse (2)

Monkey (3)

Pig (3)

Primate (1)

Rabbit (2)

Sheep (3)

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Application

IHC (19)

IHC-P (9)

WB (70)

Flo (16)

ELISA (13)

ICC (1)

IF (20)

IP (2)

Peptide-ELISA (3)

Host

rabbit (48)

mouse (30)

goat (1)

Isotype

IgG (17)

IgG1 (10)

IgG2a (8)

IgG2b (9)

IgG2b,k (1)

IgM (1)

Clonality

monoclonal mc (30)

polyclonal pc (49)

Clone

1B2 (2)

1E4 (1)

OTI11C5 (2)

OTI15F9 (2)

OTI3B8 (2)

OTI3D3 (2)

OTI5C2 (2)

OTI5D4 (2)

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OTI6C2 (2)

OTI6F3 (2)

OTI7E10 (2)

OTI8G3 (2)

SO1 (3)

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Format

12 x 8-Well Microstrips (2)

96-Well Microplate (3)

96-Well Strip Plate (20)

APC (3)

APC Conjugated (3)

Biotin Conjugated (6)

Carrier-free (11)

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Cy3 Conjugated (3)

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FITC Conjugated (5)

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PE Conjugated (3)

Unconjugated (51)

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Epitope

aa1-225 (24)

Internal (1)

aa170-220 (1)

aa213-225 (1)

aa31-80 (1)

aa71-85 (1)

Publications

No (115)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (5)

Plasma (14)

Serum (14)

Tissue Homogenates (8)

Tag

6His, N-terminus (1)

GST (1)

His (4)

His, N-Terminal (2)

His-SUMO (1)

His-TRX (1)

Myc-DDK (Flag) (1)

Species

Human (6)

Mouse (2)

Rat (3)

Source

E. coli (8)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (3)

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SOCS3 Antibody (clone OTI11C5) LS-C172981

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI11C5) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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SOCS3 Antibody (clone OTI11C5, Carrier-free) LS-C786053

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI11C5) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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SOCS3 Antibody (Internal) LS-C353123

Antibody:

SOCS3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Sheep, Bovine, Mouse, Dog, Rat, Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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Mouse SOCS3 (Sandwich ELISA) ELISA Kit - LS-F8568

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$715

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Rat SOCS3 (Sandwich ELISA) ELISA Kit - LS-F12629

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F18300

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

SOCS3 Antibody (clone OTI8G3) LS-C173025

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI8G3) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SOCS3 Antibody (clone OTI8G3, Carrier-free) LS-C786112

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI8G3) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SOCS3 Antibody (clone OTI5D4) LS-C172776

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI5D4) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SOCS3 Antibody (clone OTI5D4, Carrier-free) LS-C786015

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI5D4) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SOCS3 Antibody (aa213-225) LS-C55482

Antibody:

SOCS3 Goat anti-Human Polyclonal (aa213-225) Antibody

Reactivity:

Rabbit, Mouse, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

Human SOCS3 Protein (Recombinant 6His, N-terminus) (aa1-225) - LS-G14146

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.3 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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SOCS3 Antibody (aa71-85) LS-C312859

Antibody:

SOCS3 Rabbit anti-Human Polyclonal (aa71-85) Antibody

Reactivity:

Chicken, Sheep, Bovine, Rat, Pig, Horse, Bat, Mouse, Guinea pig, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SOCS3 Antibody (clone OTI3D3) LS-C173003

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI3D3) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SOCS3 Antibody (clone OTI3D3, Carrier-free) LS-C786079

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI3D3) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$512

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SOCS3 Antibody (aa1-225) LS-C296550

Antibody:

SOCS3 Rabbit anti-Mouse Polyclonal (aa1-225) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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SOCS3 Antibody (aa1-225, Biotin) LS-C297684

Antibody:

SOCS3 Rabbit anti-Mouse Polyclonal (aa1-225) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

SOCS3 Antibody (clone OTI7E10) LS-C173039

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI7E10) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SOCS3 Antibody (clone OTI7E10, Carrier-free) LS-C786125

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI7E10) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SOCS3 Antibody LS-C660599

Antibody:

SOCS3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SOCS3 Antibody (clone OTI3B8) LS-C173038

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI3B8) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SOCS3 Antibody (clone OTI3B8, Carrier-free) LS-C786126

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI3B8) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SOCS3 Antibody (clone OTI6C2) LS-C173019

Antibody:

SOCS3 Mouse anti-Human Monoclonal (OTI6C2) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SOCS3 Antibody (clone OTI6C2, Carrier-free) LS-C786103

Antibody:

SOCS3 Mouse anti-Human Monoclonal (Carrier-free) (OTI6C2) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F4903

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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