SOCS1

suppressor of cytokine signaling 1

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

SOCS1 (6)

Publications

No (6)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Yeast (1)

Purification

Purified (1)

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Human SOCS1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G21206

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SOCS1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23141

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

25.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human SOCS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79704

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.4 kDa

Price:

20 µg/$150

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Human SOCS1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67381

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.4 kDa

Price:

20 µg/$1,107

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Mouse SOCS1 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G137115

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

28.7 kDa

Price:

20 µg/$364; 1 mg/$1,679; 100 µg/$500

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SOCS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100114

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.4 kDa

Price:

100 µg/$494

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