SOCS1

suppressor of cytokine signaling 1

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

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Products

Antibodies (58)

ELISA Kits (10)

Proteins (6)

Type

Custom (2)

Over-Expression Lysate (2)

Primary (58)

Recombinant (4)

Sandwich (8)

Target

SOCS1 (74)

Reactivity

Human (55)

Mouse (41)

Rat (31)

Bat (9)

Bovine (9)

Chimpanzee (3)

Dog (5)

Gibbon (6)

Guinea pig (4)

Hamster (2)

Horse (6)

Monkey (5)

Pig (10)

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Application

IHC (15)

IHC-P (12)

WB (52)

Flo (2)

ELISA (15)

ICC (13)

IF (4)

IP (16)

Peptide-ELISA (4)

Host

rabbit (50)

mouse (6)

goat (2)

Product Group

IHCPlus (2)

Isotype

IgG (30)

IgG1,k (6)

Clonality

monoclonal mc (6)

polyclonal pc (52)

Clone

4H1 (1)

Format

96-Well Strip Plate (10)

APC (1)

APC Conjugated (3)

Biotin Conjugated (7)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

Magnetic beads Conjugated (1)

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C-Terminus (5)

aa107-156 (4)

aa21-70 (4)

Internal (2)

N-Terminus (2)

aa197-211 (1)

aa199-211 (1)

aa35-66 (1)

aa49-98 (1)

Publications

No (72)

Yes (2)

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Cell Culture Supernatants (1)

Cell Lysates (3)

Plasma (6)

Serum (6)

Tissue Homogenates (6)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Yeast (1)

Purification

Purified (1)

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SOCS1 Antibody (aa21-70) LS-C31894

(4.0) Rating

(1) Publication(s)

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (aa21-70) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

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IHC-plus™ SOCS1 Antibody LS-B2697

(4.0) Rating

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ SOCS1 Antibody LS-B2698

(4.0) Rating

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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SOCS1 Antibody (aa35-66) LS-C161380

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (aa35-66) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human SOCS1 (Sandwich ELISA) ELISA Kit - LS-F7983

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Human SOCS1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G21206

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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SOCS1 Antibody (N-Terminus, clone 4H1) LS-C10263

Antibody:

SOCS1 Mouse anti-Mouse Monoclonal (N-Terminus) (4H1) Antibody

Reactivity:

Mouse

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$786

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SOCS1 Antibody (Biotin) LS-C529426

Antibody:

SOCS1 Mouse anti-Mouse Monoclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, IP, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,017

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SOCS1 Antibody (APC) LS-C519282

Antibody:

SOCS1 Mouse anti-Mouse Monoclonal (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, IP, WB

Format:

APC Conjugated

Price:

100 µl/$1,017

• Unconjugated
• Biotin
• APC

• Unconjugated
• Biotin
• APC

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Mouse SOCS1 (Sandwich ELISA) ELISA Kit - LS-F32057

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human SOCS1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23141

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

25.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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SOCS1 Antibody (Internal) LS-C354123

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351

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SOCS1 Antibody LS-C409304

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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SOCS1 Antibody (Biotin) LS-C317620

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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SOCS1 Antibody (C-Terminus) LS-C10265

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$763

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SOCS1 Antibody (aa199-211) LS-C55481

Antibody:

SOCS1 Goat anti-Human Polyclonal (aa199-211) Antibody

Reactivity:

Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

Flo, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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SOCS1 Antibody (C-Terminus) LS-C122433

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$564

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SOCS1 Antibody LS-C405808

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SOCS1 Antibody LS-C402549

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SOCS1 Antibody (Preservative Free) LS-C815433

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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SOCS1 Antibody (Internal) LS-C386135

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SOCS1 Antibody LS-C484824

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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SOCS1 Antibody (C-Terminus) LS-C171844

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$380

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SOCS1 Antibody LS-C663499

Antibody:

SOCS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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SOCS1 Antibody (aa197-211) LS-C389261

Antibody:

SOCS1 Rabbit anti-Human Polyclonal (aa197-211) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Bat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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