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Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Gene Name: | small nuclear ribonucleoprotein polypeptide C |
Synonyms: | SNRPC, U1 snRNP protein C, U1C, U1 snRNP C, U1-C, Yhc1 |
Target Sequences: | NM_003093 NP_003084.1 P09234 |
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