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Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
Gene Name: | small nuclear ribonucleoprotein polypeptide A |
Synonyms: | SNRPA, U1A, Mud1, U1 snRNP A, U1 snRNP-specific protein A, U1-A |
Target Sequences: | NM_004596 NP_004587.1 P09012 |
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