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Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Gene Name: | synuclein, alpha interacting protein |
Synonyms: | SNCAIP, Synphilin-1, SYPH1, SPH1, Synphilin 1 |
Target Sequences: | NM_005460 NP_005451.2 Q9Y6H5 |
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