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SNCA / Alpha-Synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1, aSynuclein, a-Synuclein
Target Sequences: NM_000345 NP_000336.1 P37840

Publications (7)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852]
4
Reversible Conformational Conversion of a-Synuclein into Toxic Assemblies by Glucosylceramide. Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR. Neuron. 2018 January;97:92-107. [Full Text Article] [PubMed:29290548] [PMC:PMC6013314]
5
Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. Mélissa Jasmin, Eun Hee Ahn, Merja H Voutilainen, Joanna Fombonne, Catherine Guix, Tuulikki Viljakainen, Seong Su Kang, Li-Ying Yu, Mart Saarma, Patrick Mehlen, Keqiang Ye. The EMBO journal. 2021 February;40:e105537. [Full Text Article] [PubMed:33351190] [PMC:PMC7849168] Related Antibodies: LS-C380861.
6
Facile single-molecule pull-down assay for analysis of endogenous proteins. Benjamin Croop, Kyu Young Han. Physical biology. 2019 March;16:035002. [Full Text Article] [PubMed:30769341] [PMC:PMC9238377] Related Antibodies: LS-C370648.
7
UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 March;9:e2103396. [Full Text Article] [PubMed:35023303] [PMC:PMC8895126] Related Antibodies: LS-C380861.
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☰ Filters
Products
ELISA Kits (32)
Cell-Based (1)
Cell-Based Phosphorylation (3)
Competitive EIA (4)
Custom (3)
Development Kit (2)
Sandwich (17)
Sandwich CLIA (2)
SNCA / Alpha-Synuclein (32)
Human (11)
Mouse (12)
Rat (10)
Chicken (1)
Monkey (1)
Pig (1)
Porcine (1)
Rabbit (1)
Sheep (1)
Product Group
DevKit DuoPlus (2)
12 x 8-Well Microstrips (2)
96-Well Microplate (8)
96-Well Strip Plate (20)
Antibody Pair and Standard (2)
No (32)
Adherent Cell Cultures (4)
Cell Culture Supernatants (2)
Cell Lysates (2)
Plasma (21)
Serum (21)
Tissue Homogenates (7)
SNCA / Alpha-Synuclein ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
SNCA / Alpha-Synuclein ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
SNCA / Alpha-Synuclein ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
SNCA / Alpha-Synuclein ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
SNCA / Alpha-Synuclein ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
SNCA / Alpha-Synuclein ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SNCA / Alpha-Synuclein ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
SNCA / Alpha-Synuclein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SNCA / Alpha-Synuclein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SNCA / Alpha-Synuclein ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
SNCA / Alpha-Synuclein ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
500 Wells/$1,305; 1000 Wells/$1,952
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).