Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
SNCA / Alpha-Synuclein
synuclein, alpha (non A4 component of amyloid precursor)
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
| Gene Name: | synuclein, alpha (non A4 component of amyloid precursor) |
| Synonyms: | SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1, aSynuclein, a-Synuclein |
| Target Sequences: | NM_000345 NP_000336.1 P37840 |
Publications (7)
1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9.
[PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB)
[PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32.
[PubMed:22033456]
[PMC:PMC3237852]
☰ Filters
Products
Antibodies
(207)
Proteins
(51)
ELISA Kits
(32)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
(3)
Competitive EIA
(4)
Custom
(3)
Development Kit
(2)
Over-Expression Lysate
(8)
Primary
(207)
Recombinant
(43)
Sandwich
(17)
Sandwich CLIA
(2)
Target
SNCA / Alpha-Synuclein
(290)
Reactivity
Human
(193)
Mouse
(150)
Rat
(145)
Bovine
(11)
Chicken
(3)
Chimpanzee
(3)
Cow
(1)
Dog
(11)
Gibbon
(3)
Guinea pig
(3)
Hamster
(1)
Horse
(9)
Monkey
(14)
Orangutan
(3)
Pig
(11)
Porcine
(1)
Rabbit
(10)
Sheep
(8)
Application
IHC
(96)
IHC-Fr
(8)
IHC-P
(31)
WB
(187)
DB
(36)
ELISA
(112)
ICC
(11)
IF
(75)
IP
(4)
Peptide-ELISA
(16)
Host
rabbit
(139)
mouse
(59)
goat
(3)
chicken
(1)
rat
(1)
sheep
(4)
Product Group
DevKit DuoPlus
(2)
IHCPlus
(3)
PathPlus Cancer Pathology
(7)
PathPlus Neuro
(7)
Isotype
IgG
(76)
IgG1
(46)
IgG1,k
(4)
IgG2a
(1)
IgG2a,k
(3)
IgG2b
(2)
IgY
(1)
Clonality
monoclonal mc
(68)
polyclonal pc
(139)
Clone
10C299
(1)
10H7
(9)
1853CT506.24.16
(1)
2A7
(1)
2B2D1, 2B2A11
(2)
2E4
(1)
3C11
(9)
3F8
(9)
3H9
(2)
4F1
(9)
5C2
(1)
AT1E10
(1)
J18
(8)
OTI2F6
(2)
Format
12 x 8-Well Microstrips
(2)
96-Well Microplate
(8)
96-Well Strip Plate
(20)
Antibody Pair and Standard
(2)
APC
(3)
APC Conjugated
(11)
Atto 390 Conjugated
(7)
Atto 488 Conjugated
(7)
Atto 594 Conjugated
(7)
Biotin Conjugated
(15)
Carrier-free
(1)
Cy3 Conjugated
(3)
Cy7 Conjugated
(3)
FITC Conjugated
(15)
HRP Conjugated
(8)
PE Conjugated
(4)
PerCP Conjugated
(7)
Preservative Free
(1)
Ready-to-Use
(1)
RPE Conjugated
(7)
Unconjugated
(113)
Epitope
pSer129
(24)
aa23-140
(16)
C-Terminus
(9)
aa5-140
(8)
pTyr136
(7)
pTyr133
(6)
aa1-140
(5)
60-140 aa
(3)
aa108-120
(3)
aa116-131
(3)
aa91-140
(2)
pTyr125
(2)
Asp119
(1)
Glu123
(1)
Internal
(1)
Met127
(1)
N-Terminus
(1)
aa104-133
(1)
aa111-131
(1)
aa116-113
(1)
aa129-140
(1)
aa61-140
(1)
aa61-95
(1)
aa70-119
(1)
aa75-104
(1)
aa86-135
(1)
aa91-102
(1)
aa92-125
(1)
aa97-110
(1)
p125
(1)
p129
(1)
p133
(1)
pS129
(1)
pSer87
(1)
Publications
No
(288)
Yes
(2)
Sample Type
Adherent Cell Cultures
(4)
Cell Culture Supernatants
(2)
Cell Lysates
(2)
Plasma
(21)
Serum
(21)
Tissue Homogenates
(7)
Tag
6His, N-terminus
(5)
6His-SUMO, N-terminus
(1)
GST
(1)
GST, N-terminus
(2)
His
(4)
His, N-Terminal
(1)
Myc-DDK (Flag)
(12)
Species
Crab-eating macaque
(1)
Cynomolgus monkey
(1)
Human
(35)
Mouse
(8)
Rat
(2)
Source
293T Cells
(4)
E. coli
(35)
HEK 293 Cells
(8)
Wheat Germ Extract
(2)
Yeast
(2)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(11)
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pS129) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Mouse anti-Human Monoclonal (aa1-140) (5C2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (aa1-140) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Sheep, Mouse, Dog, Rat, Pig, Human
IHC-P, WB
Unconjugated
50 µl/$460
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pSer129) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$440; 100 µg/$480
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pSer87) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Goat anti-Human Polyclonal (aa91-102) Antibody
Mouse, Hamster, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SNCA / Alpha-Synuclein Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$786
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Yeast
6His, N-terminus
16.5 kD
500 µg/$1,411; 100 µg/$679; 20 µg/$429
Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SNCA / Alpha-Synuclein Chicken anti-Human Polyclonal Antibody
Rat, Pig, Cow, Horse, Mouse, Human
ICC, IF, WB
Unconjugated
100 µl/$376
Neuroscience
Cancer Pathology
SNCA / Alpha-Synuclein Goat anti-Human Polyclonal (aa97-110) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SNCA / Alpha-Synuclein Mouse anti-Mouse Monoclonal (4F1) Antibody
Mouse, Rat, Human
DB, ELISA, IF, IHC, WB
Unconjugated
100 µg/$442
SNCA / Alpha-Synuclein Rabbit anti-Human Polyclonal (pSer129) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100 µg/$570
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$311; 20 µg/$245; 1 mg/$511
Viewing 1-25
of 290
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
