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SNAP25

synaptosomal-associated protein, 25kDa

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Gene Name: synaptosomal-associated protein, 25kDa
Family/Subfamily: SNAP-25 , Not assigned-Other
Synonyms: SNAP25, BA416N4.2, DJ1068F16.2, SNAP, SUP, Super protein, RIC4, SEC9, SNAP-25, RIC-4
Target Sequences: NM_003081 NP_003072.2 P60880

Publications (3)

1
Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin. Chahboun S, Hust M, Liu Y, Pelat T, Miethe S, Helmsing S, Jones RG, Sesardic D, Thullier P. BMC biotechnology. 2011 11:113. (ELISA) [Full Text Article] [PubMed:22111995] [PMC:PMC3252318] Related Antibodies: LS-C39152.
2
Septin dynamics are essential for exocytosis. Tokhtaeva E, Capri J, Marcus EA, Whitelegge JP, Khuzakhmetova V, Bukharaeva E, Deiss-Yehiely N, Dada LA, Sachs G, Fernandez-Salas E, Vagin O. The Journal of biological chemistry. 2015 290:5280-97. (IHC; Human) [Full Text Article] [PubMed:25575596] [PMC:PMC4342448] Related Antibodies: LS-C549509.
3
Resident CAPS on dense-core vesicles docks and primes vesicles for fusion. Kabachinski G, Kielar-Grevstad DM, Zhang X, James DJ, Martin TF. Molecular biology of the cell. 2016 27:654-68. (ICC; Rat) [Full Text Article] [PubMed:26700319] [PMC:PMC4750925]

☰ Filters
Products
Proteins (16)
Over-Expression Lysate (4)
Recombinant (12)
SNAP25 (16)
No (16)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (2)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (14)
293T Cells (2)
E. coli (8)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (6)
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E. coli
6His, N-terminus
27.4 kD
100 µg/$420; 1 mg/$1,355; 20 µg/$323
SNAP25 Protein
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E. coli
His
100 µg/$317; 500 µg/$526; 20 µg/$245
SNAP25 Protein
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E. coli
None
100 µg/$317; 500 µg/$526; 20 µg/$245
SNAP25 Protein - 12.5% SDS-PAGE of human SNAP25 stained with Coomassie Blue
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Wheat Germ Extract
GST
49.7 kDa
10 µg/$479; 25 µg/$670
SNAP25 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
23.1 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$150
SNAP25 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SNAP25 Protein - Purified recombinant protein SNAP25 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$1,107
SNAP25 Protein - Purified recombinant protein SNAP25 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.1 kDa
20 µg/$1,107
SNAP25 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
23.1 kDa
100 µg/$494
SNAP25 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
100 µg/$494
SNAP25 Protein - Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) by SDS-PAGE
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E. coli
His, N-Terminal
27.0kDa
10 µg/$249; 50 µg/$307; 200 µg/$482; 100 µg/$385; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480
SNAP25 Protein - Recombinant  Synaptosomal Associated Protein 25kDa By SDS-PAGE
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E. coli
His-T7
27.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
E. coli
His
24.8 kDa
100 µg/$600
SNAP25 Protein
Select
E. coli
6His, N-terminus
26 kDa
10 µg/$265; 50 µg/$315
SNAP25 Protein
Select
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).