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Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
Gene Name: | SET and MYND domain containing 3 |
Synonyms: | SMYD3, BA74P14.1, BA74P14.1 (novel protein), KMT3E, ZMYND1, ZNFN3A1 |
Target Sequences: | NM_022743 NP_073580.1 Q9H7B4 |
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