Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Gene Name: | SET and MYND domain containing 2 |
Synonyms: | SMYD2, HSKM-B, KMT3C, Lysine N-methyltransferase 3C, ZMYND14 |
Target Sequences: | NM_020197 NP_064582.2 Q9NRG4 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.