SMURF2

SMAD specific E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SMURF2 (5)

Publications

No (5)

Tag

6His, N-terminus (1)

GST (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Yeast (1)

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Human SMURF2 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23464

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

88.2 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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SMURF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101823

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

100 µg/$494

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Human SMURF2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70914

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

20 µg/$1,107

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Human SMURF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88313

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

20 µg/$150

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Human SMURF2 Protein (Recombinant GST) (Full Length) - LS-G21950

Source:

E. coli

Tag:

GST

Molecular Weight:

113.54 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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