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Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
Gene Name: | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) |
Synonyms: | SMPD2, ISC1, NSMASE1, Sphingomyelinase neutral, N-SMase, NSMASE, Lyso-PAF-PLC, Neutral sphingomyelinase |
Target Sequences: | AJ222801 CAA10995.1 O60906 |
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