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SMPD1 / Acid Sphingomyelinase
sphingomyelin phosphodiesterase 1, acid lysosomal
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
| Gene Name: | sphingomyelin phosphodiesterase 1, acid lysosomal |
| Family/Subfamily: | Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other |
| Synonyms: | SMPD1, Acid sphingomyelinase, ASM, NPD, ASMASE |
| Target Sequences: | NM_000543 NP_000534.3 P17405 |
Publications (3)
1
Regulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes. Shamroop Kumar Mallela, Alla Mitrofanova, Sandra Merscher, Alessia Fornoni. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 December;1864:158517. [Full Text Article]
[PubMed:31487557]
[PMC:PMC6832884]
Related Antibodies: LS-C334919.
2
Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Yue-Hong Chen, Rong-Han Liu, Ya-Zhou Cui, Aubryanna Hettinghouse, Wen-Yu Fu, Lei Zhang, Chen Zhang, Chuan-Ju Liu. Arthritis research & therapy. 2022 January;24:27. [Full Text Article]
[PubMed:35045889]
[PMC:PMC8767691]
Related Antibodies: LS-C334919.
3
Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia. Xinxu Yuan, Owais M Bhat, Yao Zou, Xiang Li, Yang Zhang, Pin-Lan Li. Journal of lipid research. 2022 October;63:100298. [Full Text Article]
[PubMed:36252682]
[PMC:PMC9672920]
Related Antibodies: LS-C334919.
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SMPD1 / Acid Sphingomyelinase
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa70-340) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Sheep, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, Neut
Unconjugated
100 µg/$896
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa396-445) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa79-128) Antibody
Human
WB
Unconjugated
100 µl/$424
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa79-128) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Microplate
Human
1.22 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (aa62-341) (OTI3H7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (aa62-341) (Carrier-free) (OTI3H7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa319-579) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (aa62-341) (OTI10C5) Antibody
Human
WB
Unconjugated
100 µl/$434
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
E. coli
His-T7
33.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Sandwich
96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cerebrospinal Fluid, Plasma, Serum, Urine
1 Plate/$1,041
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (4H2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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