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SMG7
SMG7 nonsense mediated mRNA decay factor
SMG7 is a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Gene Name: | SMG7 nonsense mediated mRNA decay factor |
| Synonyms: | SMG7, EST1-like protein C, EST1C, Ever shorter telomeres 1C, HSMG-7, SGA56M, SMG-7, C1orf16, KIAA0250, Protein SMG7, SMG-7 homolog |
| Target Sequences: | NM_173156 NP_775179.1 Q92540 |
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