SMG6

SMG6 nonsense mediated mRNA decay factor

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)4GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.

☰ Filters

Products

Antibodies (6)

Proteins (2)

Type

Over-Expression Lysate (2)

Primary (6)

Target

SMG6 (8)

Reactivity

Human (6)

Mouse (1)

Rat (2)

Application

IHC (2)

IHC-P (2)

WB (2)

ELISA (4)

Peptide-ELISA (1)

Host

rabbit (6)

Product Group

IHCPlus (1)

Isotype

IgG (6)

Clonality

polyclonal pc (6)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (3)

Epitope

aa251-511 (1)

Publications

No (8)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

Select

IHC-plus™ SMG6 Antibody LS-B15630

(4.0) Rating

Antibody:

SMG6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SMG6 Antibody (aa251-511) LS-C398998

Antibody:

SMG6 Rabbit anti-Human Polyclonal (aa251-511) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

SMG6 Antibody (HRP) LS-C398986

Antibody:

SMG6 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

SMG6 Antibody (Biotin) LS-C398987

Antibody:

SMG6 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

SMG6 Antibody (FITC) LS-C398977

Antibody:

SMG6 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SMG6 Antibody LS-C803628

Antibody:

SMG6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

Human SMG6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82823

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.3 kDa

Price:

20 µg/$215

Select

SMG6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112387

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.3 kDa

Price:

100 µg/$710

Viewing 1-8 of 8 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.