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Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
Gene Name: | structural maintenance of chromosomes 1B |
Synonyms: | SMC1B, BK268H5.5, SMC1L2, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1BETA, BK268H5 |
Target Sequences: | NM_148674 NP_683515.4 Q8NDV3 |
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