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SMC1A / SMC1
structural maintenance of chromosomes 1A
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | structural maintenance of chromosomes 1A |
| Synonyms: | SMC1A, CDLS2, DXS423E, KIAA0178, SB1.8, SMC protein 1A, SMC1, SMC1L1, SMC-1-alpha, SMC-1A, SMCB |
| Target Sequences: | NM_006306 NP_006297.2 Q14683 |
Publications (1)
1
High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation. Agostinho A, Manneberg O, van Schendel R, Hernández-Hernández A, Kouznetsova A, Blom H, Brismar H, Höög C. EMBO reports. 2016 June;17:901-13. (Human)
[Full Text Article]
[PubMed:27170622]
[PMC:PMC5278604]
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Neuroscience
SMC1A / SMC1 Mouse anti-Human Monoclonal (1B9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
SMC1A / SMC1 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Rat, Pig, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$356; 100 µl/$461
Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Neuroscience
SMC1A / SMC1 Rabbit anti-Human Polyclonal Antibody
Xenopus, Mouse, Human
IF, IHC-P, IP, WB
Unconjugated
50 µg/$485
SMC1A / SMC1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
SMC1A / SMC1 Mouse anti-Human Monoclonal (5B6) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$435
SMC1A / SMC1 Rabbit anti-Human Polyclonal (pSer966) Antibody
Human
ICC, IF, IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$533
Neuroscience
SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1175-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SMC1A / SMC1 Rabbit anti-Human Polyclonal (pSer957) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMC1A / SMC1 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$391
SMC1A / SMC1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
SMC1A / SMC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Neuroscience
SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1175-C-term) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
50 µl/$460
SMC1A / SMC1 Rabbit Recombinant Monoclonal Antibody
Flo, ICC, IHC, IHC-IF, IP, WB
Unconjugated
20 µl/$299; 100 µl/$425
Neuroscience
SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1-248) Antibody
Mouse, Bovine, Human
IHC-P, WB
Unconjugated
50 µl/$460
SMC1A / SMC1 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Pig, Human
Flo, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$406; 200 µg/$505
SMC1A / SMC1 Rabbit anti-Human Polyclonal (pSer957) Antibody
IF, IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1-130) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
2 Plates/$668
SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI2D12) Antibody
Mouse, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (OTI11E1) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$434
SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (OTI5A1) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$434
SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI5A1) Antibody
Mouse, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (OTI3G4) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$434
SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI3G4) Antibody
Mouse, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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