SMARCB1 / INI1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

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Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

SMARCB1 / INI1 (11)

Publications

No (11)

Tag

6His, N-terminus (3)

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Source

293T Cells (2)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

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Human SMARCB1 / INI1 Protein (Recombinant 6His, N-terminus) (aa2-376) - LS-G23393

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

45 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human SMARCB1 / INI1 Protein (Recombinant GST) (Full Length) - LS-G30457

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.5 kDa

Price:

2 µg/$439

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Human SMARCB1 / INI1 Protein (Recombinant GST, N-terminus) (aa81-180) - LS-G60142

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99956

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

100 µg/$494

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Human SMARCB1 / INI1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67408

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

20 µg/$1,107

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Human SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79776

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

20 µg/$150

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Human SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79775

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

20 µg/$150

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SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121992

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

100 µg/$494

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Human SMARCB1 / INI1 Protein (Recombinant 6His, N-terminus) - LS-G137450

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

49.0 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SMARCB1 / INI1 Protein (Recombinant His-SUMO) (Full Length) - LS-G21691

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

59 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SMARCB1 / INI1 Protein (Recombinant 6His, N-terminus) (aa2-376) - LS-G55975

Source:

Baculovirus

Tag:

6His, N-terminus

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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