SMAD4

SMAD family member 4

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Products

ELISA Kits (18)

Type

Cell-Based (1)

Competitive EIA (1)

Custom (2)

Sandwich (13)

Sandwich CLIA (1)

Target

SMAD4 (18)

Reactivity

Human (8)

Mouse (2)

Rat (4)

Chicken (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (4)

96-Well Strip Plate (12)

Publications

No (18)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (1)

Cell Lysates (3)

Plasma (8)

Serum (8)

Tissue Homogenates (5)

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Mouse/Human/Rat SMAD4 (Cell-Based ELISA) ELISA Kit - LS-F2315

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human SMAD4 (Sandwich ELISA) ELISA Kit - LS-F5721

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Bovine SMAD4 (Custom ELISA) ELISA Kit - LS-F18825

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Pig SMAD4 (Custom ELISA) ELISA Kit - LS-F18826

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Rat SMAD4 (Sandwich ELISA) ELISA Kit - LS-F23590

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human SMAD4 (Sandwich ELISA) ELISA Kit - LS-F22013

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Rat SMAD4 (Sandwich ELISA) ELISA Kit - LS-F35508

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human SMAD4 (Sandwich ELISA) ELISA Kit - LS-F36875

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat SMAD4 (Sandwich ELISA) ELISA Kit - LS-F39606

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$783

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Mouse SMAD4 (Sandwich ELISA) ELISA Kit - LS-F38355

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human SMAD4 (Competitive EIA) ELISA Kit - LS-F27810

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human SMAD4 (CLIA) ELISA Kit - LS-F29642

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Rabbit SMAD4 (Sandwich ELISA) ELISA Kit - LS-F45800

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Chicken SMAD4 (Sandwich ELISA) ELISA Kit - LS-F45797

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey SMAD4 (Sandwich ELISA) ELISA Kit - LS-F45798

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine SMAD4 (Sandwich ELISA) ELISA Kit - LS-F45799

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Human SMAD4 (Sandwich ELISA) ELISA Kit - LS-F50041

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.3 - 300 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants

Price:

1 Plate/$610

Select

Human SMAD4 (Sandwich ELISA) ELISA Kit - LS-F52636

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

25 - 1600 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$968

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