SMAD2

SMAD family member 2

SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

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Products

ELISA Kits (15)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

DNA Binding (1)

DNA Binding Phosphorylation (1)

Sandwich (8)

Target

SMAD2 (15)

Reactivity

Human (10)

Mouse (5)

Rat (7)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (4)

96-Well Strip Plate (9)

Publications

No (15)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (1)

Cell Lysates (3)

Nuclear Lysates (2)

Plasma (7)

Serum (7)

Tissue Homogenates (3)

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Mouse/Human/Rat Phospho-SMAD2 (Ser467) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1057

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human SMAD2 (Sandwich ELISA) ELISA Kit - LS-F38230

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse SMAD2 (Sandwich ELISA) ELISA Kit - LS-F19435

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human SMAD2 (DNA-Binding ELISA) ELISA Kit - LS-F797

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Mouse/Human/Rat Phospho-SMAD2 (Ser250) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1373

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-SMAD2 (Ser250) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F908

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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Mouse/Human/Rat SMAD2 (Cell-Based ELISA) ELISA Kit - LS-F2312

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Rat SMAD2 (Sandwich ELISA) ELISA Kit - LS-F12615

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human SMAD2 (Sandwich ELISA) ELISA Kit - LS-F12614

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Bovine SMAD2 (Custom ELISA) ELISA Kit - LS-F19436

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Rat SMAD2 (Sandwich ELISA) ELISA Kit - LS-F35916

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human SMAD2 (Sandwich ELISA) ELISA Kit - LS-F35914

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat SMAD2 (Sandwich ELISA) ELISA Kit - LS-F38805

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human SMAD2 (Sandwich ELISA) ELISA Kit - LS-F39611

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$748

Select

Human SMAD2 (Custom ELISA) ELISA Kit - LS-F50725

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$823

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