SLC9A1BP / CHP

calcineurin-like EF-hand protein 1

Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

SLC9A1BP / CHP (6)

Publications

No (6)

Tag

GST (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human SLC9A1BP / CHP Protein (Recombinant GST) (Full Length) - LS-G32589

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

33 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SLC9A1BP / CHP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65119

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.3 kDa

Price:

20 µg/$1,107

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Human SLC9A1BP / CHP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74905

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.3 kDa

Price:

20 µg/$150

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SLC9A1BP / CHP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101000

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.3 kDa

Price:

100 µg/$494

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Human SLC9A1BP / CHP Protein (Recombinant His-T7) (aa2-195) - LS-G24819

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.7 kDa

Price:

10 µg/$264; 50 µg/$345; 100 µg/$540; 200 µg/$672; 1 mg/$1,676; 500 µg/$1,258; 5 mg/$2,623; 2 mg/$1,852

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Human SLC9A1BP / CHP Protein (Recombinant His) - LS-G819

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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