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6737 Mowry Ave
Newark, CA 94560
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SLC8B1 / SLC24A6 / NCLX
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange. In contrast to other members of the family its function is independent of K+.
| Gene Name: | solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
| Synonyms: | SLC8B1, NCKX6, NCLX, SLC24A6 |
| Target Sequences: | NM_024959 NP_079235.2 Q6J4K2 |
Publications (1)
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