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SLC8A3 / NCX3 is a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
Gene Name: | solute carrier family 8 (sodium/calcium exchanger), member 3 |
Family/Subfamily: | Transporter , Calcium:cation antiporter |
Synonyms: | SLC8A3, Na+/Ca2+ exchanger 3, NCX2, NCX3, Sodium-calcium exchanger 3, Sodium/calcium exchanger 3 |
Target Sequences: | NM_033262 NP_150287.1 P57103 |
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