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SLC8A1 / NCX1
solute carrier family 8 (sodium/calcium exchanger), member 1
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
| Gene Name: | solute carrier family 8 (sodium/calcium exchanger), member 1 |
| Family/Subfamily: | Transporter , Calcium:cation antiporter |
| Synonyms: | SLC8A1, CNC, NCX1, Sodium calcium exchanger 1, Sodium/calcium exchanger 1, Na+/Ca2+ exchanger, Na+/Ca++ exchanger |
| Target Sequences: | NM_021097 NP_066920.1 P32418 |
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SLC8A1 / NCX1 Mouse anti-Dog Monoclonal (aa371-525) Antibody
Rabbit, Dog, Guinea pig, Rat, Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$807
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (270-350 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa46-95) Antibody
Human
WB
Unconjugated
100 µl/$424
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa46-95) (HRP) Antibody
Chicken, Zebrafish, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
HRP Conjugated
100 µl/$469
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa46-95) (Biotin) Antibody
Chicken, Zebrafish, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa46-95) (FITC) Antibody
Chicken, Zebrafish, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
FITC Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$669
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SLC8A1 / NCX1 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rat
ELISA, IHC, WB
Unconjugated
100 µg/$832
SLC8A1 / NCX1 Rabbit anti-Rat Polyclonal (Cytoplasmic Domain) Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$832
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$375
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
SLC8A1 / NCX1 Rabbit-New Zealand White anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa296-325) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
SLC8A1 / NCX1 Rabbit anti-Rat Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Dog, Rat, Cat
ELISA, WB
Unconjugated
50 µg/$884
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (aa336-381) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
SLC8A1 / NCX1 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human
WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
Yeast
6His, N-terminus
1 mg/$1,683; 100 µg/$499; 20 µg/$364
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