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Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
Gene Name: | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
Family/Subfamily: | Transporter , Cationic amino acid transporter |
Synonyms: | SLC7A7, LPI, Lysinuric protein intolerance, Monocyte amino acid permease 2, MOP-2, LAT3, Y+L amino acid transporter 1, My+lat1, Y+LAT-1, Y+LAT1 |
Target Sequences: | NM_003982 NP_003973.3 Q9UM01 |
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