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SLC6A5 / GLYT2 is a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea.
Gene Name: | solute carrier family 6 (neurotransmitter transporter), member 5 |
Family/Subfamily: | Transporter , Neurotransmitter:sodium symporter |
Synonyms: | SLC6A5, Glycine type 2 transporter, GLYT2, Glyt2a, Glycine transporter 1, type 2, GLYT-2, HKPX3 |
Target Sequences: | NM_004211 NP_004202.2 Q9Y345 |
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