SLC3A2 / CD98 Heavy Chain

solute carrier family 3 (amino acid transporter heavy chain), member 2

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.

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Products

Proteins (20)

Type

Over-Expression Lysate (7)

Recombinant (13)

Target

SLC3A2 / CD98 Heavy Chain (20)

Application

SDS-PAGE (2)

Publications

No (20)

Tag

6His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (4)

His,N-terminus (2)

His-GST (2)

Myc-DDK (Flag) (9)

Species

Human (12)

Mouse (3)

Rat (2)

Source

293T Cells (4)

E. coli (4)

HEK 293 Cells (7)

Human Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (5)

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Mouse SLC3A2 / CD98 Heavy Chain Protein (Recombinant His-GST) (aa285-522) - LS-G15458

Source:

E. coli

Tag:

His-GST

Molecular Weight:

53.3 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant GST) (Full Length) - LS-G30431

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat SLC3A2 / CD98 Heavy Chain Protein (Recombinant His) (Ala100-Ala527) - LS-G98478

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.7 kDa

Price:

100 µg/$843

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Mouse SLC3A2 / CD98 Heavy Chain Protein (Recombinant His) (Ala139-Ala565) - LS-G98848

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.2 kDa

Price:

50 µg/$721

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SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118002

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

100 µg/$494

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Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant His) (aa213-349) - LS-G15457

Source:

E. coli

Tag:

His

Molecular Weight:

16.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Rat SLC3A2 / CD98 Heavy Chain Protein (Recombinant His-GST) (aa282-523) - LS-G15460

Source:

E. coli

Tag:

His-GST

Molecular Weight:

58.5 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant 6His, C-terminus) (Arg206-Ala630) - LS-G39043

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.89kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant His,N-terminus) (Arg206-Ala630) - LS-G47825

Source:

HEK 293 Cells

Tag:

His,N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human SLC3A2 consists of 445 amino acids and has a calculated molecular mass of 49.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSLC3A2 is approximately 65-75 kDa due to glycosylation.

Price:

100 µg/$480; 1 mg/$2,003

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Mouse SLC3A2 / CD98 Heavy Chain Protein (Recombinant His,N-terminus) (Ala139-Ala565) - LS-G48984

Source:

HEK 293 Cells

Tag:

His,N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse SLC3A2 comprises 446 amino acids and predicts a molecular mass of 49.2 kDa. As a result of glycosylation, the apparent molecular mass of mouse SLC3A2 is approximately 60-70 kDa in SDS-PAGE under reducing conditions.

Price:

50 µg/$441; 1 mg/$2,272

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Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64758

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

20 µg/$1,107

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Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64759

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.6 kDa

Price:

20 µg/$1,107

Select

Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant GST, N-terminus) (aa203-312) - LS-G60112

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99275

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

100 µg/$494

Select

Human SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74097

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

20 µg/$150

Select

Human SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74100

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.6 kDa

Price:

20 µg/$215

Select

Human SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74102

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

20 µg/$150

Select

Human SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74101

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

20 µg/$150

Select

SLC3A2 / CD98 Heavy Chain Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121345

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.6 kDa

Price:

100 µg/$710

Select

Human SLC3A2 / CD98 Heavy Chain Protein (Recombinant His) (aa270-406) - LS-G15451

Source:

E. coli

Tag:

His

Molecular Weight:

16.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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