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SLC30A8 / ZNT8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.
Gene Name: | solute carrier family 30 (zinc transporter), member 8 |
Family/Subfamily: | Transporter , Cation diffusion facilitator |
Synonyms: | SLC30A8, ZNT8, Zinc transporter 8, Zinc transporter ZnT-8, ZnT-8 |
Target Sequences: | NM_001172811 NP_001166282.1 Q8IWU4 |
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