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Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Gene Name: | solute carrier family 22, member 17 |
Family/Subfamily: | Transporter , Organic cation transporter |
Synonyms: | SLC22A17, 24p3 receptor, 24p3R, BOIT, BOCT, HBOIT, NGALR, NGAL receptor, NGALR2, Lipocalin-2 receptor, MBOCT, NGALR3 |
Target Sequences: | NM_020372 NP_065105.2 Q8WUG5 |
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