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SLC1A2 / EAAT2 / GLT-1

solute carrier family 1 (glial high affinity glutamate transporter), member 2

SLC1A2 / EAAT2 / GLT-1 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.

Gene Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Family/Subfamily: Transporter , Sodium:dicarboxylate symporter
Synonyms: SLC1A2, EAAT-2, GLT-1, Glutamate transporter 1, EAAT2, GLT1
Target Sequences: NM_004171 NP_004162.2 P43004

Publications (2)

1
Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses. Tse DY, Chung I, Wu SM. Vision research. 2014 103:49-62. (IHC; Rat) [Full Text Article] [PubMed:25152321] [PMC:PMC4547049] Related Antibodies: LS-C15448.
2
Unbiased Proteomic Approach Identifies Pathobiological Profiles in the Brains of Preclinical Models of Repetitive Mild Traumatic Brain Injury, Tauopathy, and Amyloidosis. Joseph O Ojo, Gogce Crynen, Moustafa Algamal, Prashanti Vallabhaneni, Paige Leary, Benoit Mouzon, Jon M Reed, Michael Mullan, Fiona Crawford. ASN neuro. 2020 Jan-Dec;12:1.75909142091476E+15. [Full Text Article] [PubMed:32241177] [PMC:PMC7132820]

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Proteins (4)
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SLC1A2 / EAAT2 / GLT-1 (4)
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GST (3)
GST, N-terminus (1)
Human (2)
Mouse (2)
E. coli (1)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
SLC1A2 / EAAT2 / GLT-1 Protein - 12.5% SDS-PAGE of human SLC1A2 stained with Coomassie Blue
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Wheat Germ Extract
GST
88.5 kDa
2 µg/$439
SLC1A2 / EAAT2 / GLT-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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E. coli
GST
38 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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Yeast
GST
37.3 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).