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SLC19A1
solute carrier family 19 (folate transporter), member 1
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
| Gene Name: | solute carrier family 19 (folate transporter), member 1 |
| Family/Subfamily: | Transporter , Reduced folate carrier |
| Synonyms: | SLC19A1, CHMD, IFC1, Folate transporter 1, FOLT, IFC-1, Intestinal folate carrier 1, Reduced folate transporter, REFC, Folate transporter, Intestinal folate carrier, Placental folate transporter, Reduced folate carrier 1, Reduced folate carrier protein, RFC |
| Target Sequences: | NM_194255 NP_919231.1 P41440 |
Publications (1)
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