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SLC18A1 / VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).
| Gene Name: | solute carrier family 18 (vesicular monoamine transporter), member 1 |
| Family/Subfamily: | Transporter , Vesicle amine transporter |
| Synonyms: | SLC18A1, CGAT, Vesicular amine transporter 1, VMAT1 |
| Target Sequences: | NM_003053 NP_003044.1 P54219 |
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