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Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO3-/H+ cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
Gene Name: | solute carrier family 17 (acidic sugar transporter), member 5 |
Family/Subfamily: | Transporter , Lysosomal sialate transporter |
Synonyms: | SLC17A5, AST, Membrane glycoprotein HP59, SD, Sialin, SIASD, NSD, Sialic acid storage disease, SLD, ISSD |
Target Sequences: | NM_012434 NP_036566.1 Q9NRA2 |
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