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Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na+ cotransport.
Gene Name: | solute carrier family 17 (organic anion transporter), member 3 |
Family/Subfamily: | Transporter , Sodium:phosphate symporter |
Synonyms: | SLC17A3, Na(+)/PI cotransporter 4, NPT4 |
Target Sequences: | NM_006632 NP_006623.2 O00476 |
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